منابع مشابه
Computational Analysis of Protein Tyrosine Nitration
As an important covalent post-translational modification, Tyrosine nitration is closely related to the causes of various diseases. However, its mechanism is still largely unknown. Based on experimentally verified tyrosine nitration sites, we introduced a novel computational approach to analyze tyrosine nitration. Nearest Neighbor algorithm armed by maximum relevancy minimum redundancy feature s...
متن کاملNitric oxide, oxidants, and protein tyrosine nitration.
The occurrence of protein tyrosine nitration under disease conditions is now firmly established and represents a shift from the signal transducing physiological actions of (.)NO to oxidative and potentially pathogenic pathways. Tyrosine nitration is mediated by reactive nitrogen species such as peroxynitrite anion (ONOO(-)) and nitrogen dioxide ((.)NO2), formed as secondary products of (.)NO me...
متن کاملProtein tyrosine nitration in pea roots during development and senescence
Protein tyrosine nitration is a post-translational modification mediated by reactive nitrogen species (RNS) that is associated with nitro-oxidative damage. No information about this process is available in relation to higher plants during development and senescence. Using pea plants at different developmental stages (ranging from 8 to 71 days), tyrosine nitration in the main organs (roots, stem...
متن کاملEffects of cigarette smoke on salivary protein tyrosine nitration
INTRODUCTION Nitration of tyrosine and tyrosine-containing proteins and their roles in pathophysiology have just recently been reviewed. Despite low yields of tyrosine modifications, nitration of tyrosine residues may inactivate important proteins. Nitrotyrosine can be formed by various nitrating agents, including peroxynitrite. Thus, the occurrence of nitrotyrosine-containing proteins in vivo ...
متن کاملDesferrioxamine inhibits protein tyrosine nitration: mechanisms and implications.
Tissues are exposed to exogenous and endogenous nitrogen dioxide ((·)NO(2)), which is the terminal agent in protein tyrosine nitration. Besides iron chelation, the hydroxamic acid (HA) desferrioxamine (DFO) shows multiple functionalities including nitration inhibition. To investigate mechanisms whereby DFO affects 3-nitrotyrosine (3-NT) formation, we utilized gas-phase (·)NO(2) exposures, to li...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Plant Signaling & Behavior
سال: 2009
ISSN: 1559-2324
DOI: 10.4161/psb.4.10.9466